For the largest pre-war engines, check here:
en.wikipedia.org/wiki/List_of...e_superlatives
Go to the very bottom of the page. Largest is a 21.5L 4-cylinder!
Sadly, even the 500 has been surpassed recently. By 1%... 2003 Viper with 505ci.
anyways, back to the thread...
A 500ci motor will make more power and torque than a 425 given equal emissions equipment and exhaust. 75ci of extra fuel and air being pulled in each intake stroke will make a difference. It's the same reason that people stroke their motors to go faster. Just because the factory only had 180hp out of a hugely de-tuned 500ci motor does not show the motors potential. By the same token, you could swap in any number of V6's made in the last 20 years that also make 180hp and then build that up, but it wouldn't get you the goal you are after.
I might just have to snag a 425 out of the junkyard and weigh it... I actually re-checked my data and found that the 472/500 motors are more than 60# heavier than a 350 SBC, but if a 425 comes in light enough. hmmmm...
I guess the direction of this thread shows the fate of the 368. Red-headed stepchild of the bunch I suppose. Only a product of the fuel economy requirements that started in the late '70's and probably never would have existed otherwise. Cadillac probably could have kept the 425 motor up with emissions regs for longer with better EFI systems, but that combined with fuel economy requirements forced Cadillac to make do with shrinking down their big block untill a new engine family could be designed.
Logically, I suppose one would put in a 400ci Chevy smallblock before a 368. The 400 motor weighs less, costs less, has tremendous aftermarket support, etc... But, that wouldn't be a Caddy motor then, and that's the whole point here. I'm pretty sure you already have a bellybutton haha.
I suppose if you just can't find anything larger than a 368 to replace the 4100, then go for it. Coming from the 4100, it will probably feel like a sports car anyways. 1.9L more - it's like you've got an extra engine under the hood! Of course, be prepared to long for even more power and the urge to swap in a larger Big Cad when you find one