The 500 is the largest **V8** ever used in a regular production car. Lets not get into double digit cylinders and industrial or crate engines. The 500 was the largest V8 ever put into a passenger car that roled down an assembly line.
As for direct swaps with the HT4100 look to Oldsmobile. The Olds 350 and 403 are pretty direct swaps. An Olds 455 can be made to fit, but it has a higher deck height than the 350 and 403 so you'll need to do some modifications. You just need the motor mounts, brackets, etc. from a Diesel Caddy (The GM Diesel of the early 80s was based on the Olds 350).